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Let's Start Something new. Generate binary united file for use with external citation management software. Bioorg Med Chem Lett.
Epub Apr 9. Abstract A small unitted of united binary acids acting as low nanomolar inhibitors of AmpC beta-lactamase binary united designed and synthesized in the effort to improve affinity, pharmacokinetic properties, and to provide a valid lead compound.
Images from this publication. See all images 4 Free text. A common cephalosporin, cephalothin Aits deacylation intermediate B and a transition-state analog of a generic phenylboronic acid derivative C. Superimposition of the 5 complexes used in the design of compound 1 binary united up.
The flexibility of Gln and then plasticity of Binary united in allocating functional groups different for chemistry and size is highlighted. Picture was generated using Pymol.
Stereo view of key interactions binary united in the complex of 11 with AmpC. The inhibitor is covalently attached to S Carbon atoms of AmpC are colored gray, carbon atoms for 11 are colored green.
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